Quinapril: Overview of preclinical data

Cannabidiol and Cancer — An Overview of the Preclinical Data

Preclinical toxicology studies with the angiotensin-converting enzyme inhibitor quinapril hydrochloride (Accupril).

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the ki...

Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical data.

Mental disorders, such as depression and anxiety, pose both medical and social challenges. The clinical efficacy of current antidepressant/anxiolytic therapies is unsatisfactory; both antidepressant and anxiolytic drugs induce a variety of unwanted effects and have delayed onsets of action. Thus, a search for better and safer agents is continuously in progress. Preclinical results published so ...

The Preclinical Data

Despite several drugs for the treatment of hypertension, there are many patients with poorly controlled high blood pressure. This is partly because all of the available drugs are short-lasting (#24 hours), have side effects, and are not highly specific. Gene therapy offers a possibility of producing longer-lasting effects with precise specificity based on the genetic design. Preclinical studies...

Screening of Nootropics: an Overview on Preclinical Evaluation Techniques

Nootropics are also referred as smart drugs, memory enhancers, and cognitive enhancers. They are reported to improve mental function such as cognition, memory, intelligence, motivation, attention and concentration. They are thought to be work by altering the availability of brains supply of neurochemicals, by improving the brains oxygen supply or by stimulating nerve growth. Alzheimer’s disease...